Mark Cullen, MD, trained in medicine and clinical epidemiology at Yale, Cullen spent the first two decades building the Yale Occupational and Environmental Medicine Program exploiting clinical, biologic and analytic resources of that unique medical school environment. During this period, he served on numerous public and private occupational health advisory positions including, the MacArthur Research Network on Socioeconomic Status and Health. Since 1997 Cullen‚Äôs research has morphed towards larger-dataset social and environmental epidemiology. His ‚ÄúAlcoa Study‚Äù has resulted to date in over 60 papers and trained over 30 doctoral and post-doctoral students in medicine, epidemiology, biostatistics, and economics. Major target areas of interest include developing a model for the systematic causes of disease and disability deaths. He was elected to the IOM in 1997.